Our services caters the needs of the Biopharmaceutical Companies, Research Institutes and Drug discovery Companies to fasten the research and facilitate new scientific findings by giving the most promising products, by shortening their research time and costs.
1) Biological sequence annotation and assembling
Biological sequence assembly is an essential step for sequencing the genomes of organisms. Sequence assembly is very computing intensive. If there is a raw sequence by the client then all the necessary annotation will be done by our team as per the client needs. Similar sequences will be annotated and assembled as a single cluster.
a) Genome annotation and analysis
Experimental data output has considerably grown in size and complexity. BioAxis DNA Research centre helps scientists to save time and improve quality by providing leading-edge software technologies for data analysis. We assign the functional and morphological classification as per the clients needs by creating the genome knowledge repositories and gene regulation studies. Mutation detection, Alternatively spliced gene detection as well as SNP Analysis will also be handled as per the client’s need.
b) Protein sequence annotation and characterization
Proteins are always considered as the first rank entities for the Drug development processes, Vaccine development or Disease diagnostic marker identifications. We at BioAxis DNA Research centre provide the most accurate protein annotation which may be used for client specific purposes. Our scientists are capable of Protein Identification and characterization, Protein- protein interactions as well as the post transcriptional modification studies.
2) Biological sequence identification
In many fields, such as genomic sequencing and analysis, it may be desirable to identify repetitive sequences of interest in a data series, either to assist in compression and manipulation of the data or to facilitate analysis. Further, it may be desirable to identify such sequences in a computationally efficient manner and also determining the function of a gene by finding a similar gene in another organism with a known function. So here we use BLAST for solving the problem of identifying an unknown sequence. BDRC can help the scientists to improve the quality in their research work in different area.
3) Comparative genomics: e.g. finding drug targets by comparing pathways from human and pathogen.
With the sequencing of complete genomes, it is now possible to reconstruct the network of biochemical reactions in many organisms, from bacteria to human. A grand challenge in the post-genomic era is to enable computational prediction of higher-level complexity of cellular processes and organism behaviors from genomic and molecular information. We screen the most appropriate and accurate Metabolic pathways as per the client needs to cross check whether the protein is involved in some other pathway or not disturbing
4) Phylogenetic analysis and custom tree generation
Phylogenetic analysis is the process used to determine the evolutionary relationships between organisms. The result of a phylogenetic analysis is expressed in a phylogenetic tree from which we can deduce the evolutionary relationship and find out the conserved pattern. The branches in a tree are based on the hypothesized evolutionary relationships (phylogeny) between organisms. This study can be helpful for those clients who are interested in analysis of morphological and custom molecular data. Phylogenetic analysis plays a vital role in identification of species. Comparisons of more than two sequences and analysis of gene families, including functional predictions, microbial identification services are undertaken by us.
5) Characterisation of gene regulatory elements.
Gene expression is a multi-step process in which the expression of particular genes may be assessed with DNA microarray technology, we do expression profiling, which can provide a rough measure of the cellular concentration of different messenger RNAs; often thousands at a time. BioAxis DNA Research centre is focused on discovering associations between genetic variations and disease, with this; we intend to develop diagnostic products, Analysis of effective drug and vaccines combinations that provide medically relevant information for physicians, patients, and the scientists. Such tests may help physicians to better predict, diagnose, monitor and treat some of today’s significant and complex health problems. They can prescribe a right drug combination to a right patient at the right time. In the biological research labs this is very much useful for the genetic disorder analysis.
6) Rational Drug Designing and identifying drug targets
Structure-based drug design aims to create an inhibitor that will bind to the active site of a targeted enzyme, thereby preventing the normal chemical and physiological reaction and ultimately halting the progression of the disease. In structure-based drug design, scientists use detailed knowledge of the targeted sites of protein targets associated with particular diseases to design synthetic compounds that fight the disease. Our main interests lie in the field of “rational drug design”, where we try to fuse the experimental structural data and thermodynamic measurements of protein ligand interactions in a computational framework to advance the drug discovery process.
Our experienced bioinformatics team is creating a better understanding of how small molecule drugs interact with targets.
7) Toxicity Studies (Adme Prediction)
Here, we describe how in silico approaches will further increase ability to predict and model the most relevant pharmacokinetic, metabolic and toxicity endpoints, thereby accelerating the drug discovery process. These are important for the clients who are involved in drug discovery process to evaluate the safety of potential drug candidates.
8) Vaccine Screening from the proteome
Vaccine research is one of the most upcoming fields after the drug development. We provide the cost effective screened and the most effective and appropriate vaccine candidates from the whole proteome for the client specific purposes. Our services will include the identification of cell surface antigens for the vaccine research purposes. We at BDRC also perform the data analysis for the vaccine efficacy.
9) Database Development And Maintainence
New technologies in genomics and proteomics yield large amounts of data. Our efficient data management gives you rapid access to any information, whether it is for scientific evaluation, improvement of workflow management or to assess quality control. We simplify access to heterogeneous data sources by providing easy to use, web based user interfaces. After analysis of your specific needs, we suggest a database system which serves your interests best. We also offer solutions for data storage problems as they might occur for storage and retrieval of multidimensional data.
10) Data Mining, Data Analysis
We are capable of mining the client specific data. Generally, data mining (sometimes called data or knowledge discovery) is the process of analyzing data from different perspectives and summarizing it into useful information – information that can be used to increase revenue, cuts costs, or both. It allows users to analyze data from many different dimensions or angles, categorize it, and summarize the relationships identified. Our scientists and professionals will be defining sophisticated statistical analysis generating graphical outputs where appropriate. This will add value to your data by integrating external genomics and proteomics databases. Systemic analysis of adverse effects and risk factors to a disease/infection/drug to generate new hypothesis and identifying the toxicity reasons is also done as per the client need.
11) Biological Intellectual Property Management
Today a matter of growing concern in any knowledge-based industry is “protection of research results prior to its public dissemination” termed popularly as Intellectual Property Rights (IPR). We provide guidance in this aspect through the different key forms involved.
12) Medical Content Development
Our key offerings in this domain are comprehensive range of high-quality writing, editorial, and publishing services, creating abstracts related to the field of medicine. Our medical content services offer tremendous cost cutting opportunities without compromising on the high degree of quality, accuracy and knowledge that you need. We suggest the most effective communication plans.
13) Protein Modeling
We present a new approach for modeling ligands into binding sites of proteins with unknown 3D-structure. This approach is based on generating a homology model of the query protein. It caters the need of pharmaceutical industry to design protein constructs and enhance protein production, solubility and crystallization so that it can be established as a viable pharmaceutical target.
14) Microarray Data Analysis
Microarrays are a relatively new technology to investigate the expression levels of thousands of genes simultaneously. Microarray data analysis tasks is being done here that include predictive modeling and pattern-detection analysis techniques. Predictive modeling is concerned with predictive classification or function estimation.Pattern-detection detects unknown relationships from available expression data.